Aginko
Disc models
Small and large animal models of intervertebral disc (IVD) degeneration are of great value to study the progression of the disease and to validate the safety and the efficiency of new therapeutic treatments.

Usually one has to prove and validate safety and efficiency of therapeutical treatment first on small and then on large animals such as:
  • Mouse
  • Rat
  • Rabbit
  • Dog
  • Goat and sheep
  • Pig

 


 
 

 

 

 

 

 

 

 

 

 

Fluoroscopic picture of a      MRI picture pointing out 2        MRI picture of a healthy

needle inside a rabbit disc            degenerated discs in            rabbit spine

a rabbit 


Reproducibility, progression and severity of the induced degeneration vary according to the nature of the injury and the animal species. The nature of the injury can be of chemical (papain), physical (nucleus puncture, annulus fibrosus stab) or mechanical origin to injure the IVD and to cause the degeneration. 
 

Repair of the IVD can be assessed using in vivo and ex-vivo imaging such as X-rays (to assess the Disc High Index) and MRI (qualitative and quantitative analysis), immunohistology, biochemical and molecular analyses.

Example of possible disc staining on histological slides


 

 

 

 

 

 

 

 

 

 
 

HE staining               Toluidine blue staining         Masson Trichrome           Safranin-O staining

       staining

To read more on Disc Models, Click Here


 

 

 

 

Copyright © 2017 Allrights reserved
AGINKO Research AG
AGINKO Research AG, Route de l'ancienne Papeterie 7
1723 Marly , Switzerland