Fracture models
Fracture healing is a complex physiological process where the bone and its neighboring tissues play important roles. Thus, fracture healing can only be assessed in animal models.
However, the choice of the most appropriate animal model for fracture repair remains an unanswered question as no animal model accurately reproduces the human bone physiology, biology, structure and biomechanics.
Despite these limitations, small and large animal models have been developed to study the effects of bone substitutes, scaffold, biologics or cell-based products on bone fracture repair.

Fracture bone healing is usually an optimal biological process. However, delayed healing or non-union can occur on patients for multiple reasons. In addition, bone fractures are more frequent and more problematic in osteoporotic patients as the bone structure is compromised. Fracture model, segmental and critical-size defect models have been developed in several species.

Aginko offers different in-vivo models:

Critical-size defects:
  • Calvarias critical-size defects in rats, rabbits
  • Mandibular critical-size defects in mini-pigs and dogs 
  • Femur critical-size defects in rats 
  • Ulna critical-size defects in rabbits 
  • Tibial critical-size defects in sheep and mini-pigs

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