Aginko
Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder that principally attacks the joints, producing an inflammatory synovitis that often progresses to destruction of the articular cartilage and ankylosis of the joints.

 

Aginko performs contract studies in established mouse and rat models of rheumatoid arthritis to test the efficacy of novel compounds. 

 

 

Some of the models available encompass :

  • Collagen-Induced Arthritis (CIA) in Rats
  • Collagen-Induced Arthritis (CIA) in Mice
  • Collagen Antibody-Induced Arthritis (CAIA) in Mice
  • Adjuvant Arthritis
  • Genetically manipulated or spontaneous arthritis models (i.e. TNF-alpha transgenic mouse, K/BxN mouse... )

 

Readouts generally include arthritis score, paw thickness, body weight. In option, Biomarkers (protein, mRNA), cell populations ny FACS, histology and immunohistochemistry, pharmacokinetics and pain assessment can be performed. 

 

 

 

 

 

Example of  scoring system for evaluation of arthritis severity

 

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AGINKO Research AG
AGINKO Research AG, Route de l'ancienne Papeterie 7
1723 Marly , Switzerland